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Published: 2008

Scaling Up Programmatic Management of Drug-Resistant Tuberculosis: A Prioritized Research Agenda

Frank G.J. Cobelens, et al

PLoS Medicine



Published: 2008

Getting Diagnostics Into Countries

Vinand Nantulya

Article [pdf 560kb]

More Health Partnerships Review articles on the debate about the future role of PDPs



Published: 2008

Commercial Nucleic-Acid Amplification Tests for Diagnosis of Pulmonary Tuberculosis in Respiratory Specimens: Meta-Analysis and Meta-Regression

Ling DI, Flores LL, Riley LW, Pai M

PLoS ONE (2008) 3(2): e1536

[requests for pdf]

Published: 2008

Analytical Sensitivity Limits for Lateral Flow Immunoassays

Gordon J and Michel G

July 1 2008 Clin Chem;54:1248

Supplementary data file [pdf 137kb]


A Database of Publications on Lateral Flow Immunoassays and Review of Limits of Detection

Abstract Clinical Chemistry, Vol. 54, No. 6, Supplement, 2008



Published: 2007

Nucleic acid amplification tests for the diagnosis of tuberculous lymphadenitis: a systematic review

Daley P, Thomas S, Pai M

Int J Tuberc Lung Dis 2007; 11(11): 1166-1176

[requests for pdf]

Published: 2007

Facing the crisis: improving the diagnosis of tuberculosis in the HIV era

Perkins MD, Cunningham J

J Infect Dis. 2007 Aug 15;196 Suppl 1:S15-27

[requests for pdf]

Published: 2007

A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis

Karen R Steingart, Megan Henry, Suman Laal, Philip C Hopewell, Andrew Ramsay, Richard Menzies, Jane Cunningham, Karin Weldingh, and Madhukar Pai

Thorax 2007 Aug 10.1136/thx.2006.075754

[requests for pdf]

Published: 2007

Diagnosis of smear-negative pulmonary tuberculosis in people with HIV infection or AIDS in resource-constrained settings: informing urgent policy changes

Getahun H, Harrington M, O'Brien R, Nunn P.

Lancet 2007 Jun 16;369(9578):2042-9

[requests for pdf]

Published: 2007

Recent advances in the diagnosis of childhood tuberculosis

Marais, BJ & Pai, M

Arch. Dis. Child. 2007; 92:446-452

[requests for pdf]

Published: 2007

Biomarkers of treatment response in clinical trials of novel antituberculosis agents

Felicity MR Perrin, Marc CI Lipman, Timothy D McHugh, Stephen H Gillespie

Lancet Infect Dis 2007

[requests for pdf]

Published: 2007

Serial Testing for Tuberculosis: Can We Make Sense of T Cell Assay Conversions and Reversions?

Madhukar Pai, Richard O'Brien

PLoS Medicine

[free download]

Read CBS news article



Published: 2007

Commercial Serological Antibody Detection Tests for the Diagnosis of Pulmonary Tuberculosis: A Systematic Review

Karen R. Steingart, Megan Henry, Suman Laal, Philip C. Hopewell, Andrew Ramsay, Dick Menzies, Jane Cunningham, Karin Weldingh, Madhukar Pai

PLoS Medicine

[free download]

Published: 2007

Yield of serial sputum specimen examinations in the diagnosis of pulmonary tuberculosis: a systematic review

Mase S, Ramsay A, Ng N, Henry M, Hopewell PC, Cunningham J, Urbanczik R, Perkins M, Aziz MA, Pai M

Int J Tuberc Lung Dis 2007;11(5):485-95

[requests for pdf]

Published:2007

The prognosis of latent tuberculosis: can disease be predicted?

Peter Andersen, Mark Doherty, Madhukar Pai, Karin Weldingh

Trends Mol Med 2007

[requests for pdf]

Published:2007

Meta-analysis: New Tests for the Diagnosis of Latent Tuberculosis Infection: Areas of Uncertainty and Recommendations for Research

Dick Menzies, Madhukar Pai and George Comstock

Annals of Internal Medicine

[requests for pdf]

Published:2007

Low Sensitivity of a Whole-Blood Interferon-γ Release Assay for Detection of Active Tuberculosis

Puneet K. Dewan, Jennifer Grinsdale, and L. Masae Kawamura

Clin Infect Dis 2007;44:69-73

[requests for pdf]

Published:2007

Interferon-γ Release Assays: What Is Their Role in the Diagnosis of Active Tuberculosis

Madhukar Pai and Dick Menzies

Clin Infect Dis 2007;44:74-77

[requests for pdf]

Published: August 2007

A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis

Karen R Steingart, Megan Henry, Suman Laal, Philip C Hopewell, Andrew Ramsay, Richard Menzies, Jane Cunningham, Karin Weldingh, and Madhukar Pai

Thorax 2007 - published ahead of print on 3 August 2007, 10.1136/thx.2006.075754

[download abstract]  [requests for pdf

Published: June 2007

Longitudinal Assessment of an ELISPOT Test for Mycobacterium tuberculosis Infection

[free download]

Published: May 2007

New TB textbook

[free download]

Published: May 2007

Pathway to Patients: Charting the Dynamics of the Global TB Drug Market

by the Global Alliance for TB Drug Development

[free download]

Published: Apr 2007

Fluorescence microscopy for tuberculosis diagnosis 

Nguyen VH, Dinh NS, Anthony RM, Cobelens FG, van Soolingen D

Lancet Infect Dis. 2007 Apr;7(4):238-9

[requests for pdf]

Published: 2007

Reducing the global burden of tuberculosis: the contribution of improved diagnostics

Emmett Keeler, Mark D. Perkins, Peter Small et al.

Nature Microbiology

[download pdf 692kb]

Published: March 2007

From TB tests, just a 'yes or no' answer, please

Emma Marris

Nature Medicine - 13, 267 (2007) Published online: 28 February 2007; | doi:10.1038/nm0307-267

[download full text]

Published: March 2007

From magic bullets back to the Magic Mountain: the rise of extensively drug-resistant tuberculosis

Susan E Dorman & Richard E Chaisson

Nature Medicine - 13, 295 - 298 (2007) doi:10.1038/nm0307-295

[download full text]

Published: March 2007

Changing funding patterns in tuberculosis

Stefan H E Kaufmann & Shreemanta K Parida

Nature Medicine - 13, 299 - 303 (2007) doi:10.1038/nm0307-299

[download full text]

Published: 2006

Sputum processing methods to improve the sensitivity of smear microscopy for tuberculosis: a systematic review

Steingart KR, Ng V, Henry M, Hopewell PC, Ramsay A, Cunningham J, Urbanczik R, Perkins MD, Aziz MA, Pai M.

Lancet Infect Dis 2006;6:664-74

   [download abstract]  [requests for pdf]  [about systematic reviews]

Published: 2006

Fluorescence versus conventional sputum smear microscopy for tuberculosis: a systematic review

by Steingart KR, Henry M, Ng V, Hopewell PC, Ramsay A, Cunningham J, Urbanczik R, Perkins M, Aziz MA, Pai M.

Lancet Infect Dis 2006;6:570-81

   [download abstract]  [requests for pdf]

Published: November 2006

Colorimetric redox-indicator methods for the rapid detection of multidrug resistance in Mycobacterium tuberculosis: a systematic review and meta-analysis

Anandi Martin, Francoise Portaels, and Juan Carlos Palomino

J. Antimicrob. Chemother. - 10.1093/jac/dkl477

[download full text]

Published: October 2006

Diagnostics for Tuberculosis: Global Demand and Market Potential

[more information]

Published: October 2006

Partnering for better microbial diagnostics

Tests for identifying the world's most important microbial pathogens are antiquated, inaccurate and inadequate. Innovative public-private partnership is needed to develop and produce new infectious disease diagnostics that are more rapid and of greater accuracy and sensitivity.

by Mark Perkins & Peter Small

Nature Biotechnology - 24, 919 - 921 (2006) doi:10.1038/nbt0806-919  

[download full text]

A doctor examining the back and lungs of a female patient WHO/TDR/Crump
A doctor examining the back and lungs of a female patient

Published: October 2006

Tuberculosis Research & Development: A Critical Analysis

by Cindra Feuer

The Treatment Action Group has recently completed a detailed analysis of global funding flows for tuberculosis research and development. The sources and destinations of nearly 200 millionUS$ of funds is described, and a call made for dramatic increases in funding to address critical research needs.

[download pdf]

Published: October 2006

FIND Annual Report 2005

[download pdf 911kb]

Published: July 2006

Tuberculosis diagnostics trials: do they lack methodological rigor?

by Madhukar Pai & Richard O'Brien

Expert Review of Molecular Diagnostics, July 2006, Vol. 6, No. 4, Pages 509-514

[download pdf]

Published: June 2006

Controlling Infectious Diseases

by Mary M. Kent and Sandra Yin

Including Special Sections on Diarrheal Diseases, Malaria, Tuberculosis, and Pandemics

The Population Bulletin - Population Reference Bureau (PRB) June 2006

[download pdf]

Published: May 2006

Serial testing of health care workers for tuberculosis using interferon-γ assay

by Madhukar Pai, Rajnish Joshi, Sandeep Dogra, Deepak K. Mendiratta, Pratibha Narang, Shriprakash Kalantri, Arthur L. Reingold, John M. Colford, Jr., Lee W. Riley and Dick Menzies

American Journal of Respiratory and Critical Care Medicine Vol 174. pp. 349-355, (2006)

[download full text]

Healthcare worker in rural India undergoing blood draw for QuantiFERON-TB Gold In Tube Healthcare worker in rural India undergoing blood draw for QuantiFERON-TB Gold In Tube

Published: April 2006

A new initiative for the development of new diagnostic tests for human African trypanosomiasis

by Dietmar Steverding

FIND and WHO collaborate in the development of urgently needed diagnostic tools for identifying sleeping sickness. It is hoped that the new tests will allow for early case detection and simplified staging that will improve disease management and ultimately support the elimination of sleeping sickness as a public health problem.

Kinetoplastid Biology and Disease 2006

[download full text]

Tsetse fly Tsetse fly of the genus Glossina transmits trypanosome - the parasite that causes sleeping sickness

Published: May 2006

Comparison of a whole blood interferon-γ assay with tuberculin skin testing for the detection of tuberculosis infection in hospitalized children in rural India

by Sandeep Dogra, Pratibha Narang, Deepak K. Mendiratta,Pushpa Chaturvedi, Arthur L. Reingold, John M. Colford, Jr., Lee W. Riley and Madhukar Pai

Journal of Infection 2006

Abstract from PubMed

PDF requests

Screening of household childhood contacts Screening of household childhood contacts for TB infection, India
(blood being drawn for QuantiFERON-TB Gold In Tube)

Published: May 2006

State-of-the-art reviews on new TB diagnostics

by Madhukar Pai, Shriprakash Kalantri and Keertan Dheda

New tools and emerging technologies for the diagnosis of tuberculosis: Part I. Latent tuberculosis

Expert Rev. Mol. Diagn. 6(3), 413-422 (2006)  [download pdf 315kb]

New tools and emerging technologies for the diagnosis of tuberculosis: Part II. Active tuberculosis and drug resistance

Expert Rev. Mol. Diagn. 6(3), 423-432 (2006)  [download pdf 821kb]