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FIND Newsletter Issue 7
 
Special edition on HAT - December 2007

Providing an open-access, well-characterized specimen bank

The World Health Organization’s Department of Neglected Tropical Diseases (NTD) and FIND are establishing a Specimen Bank to provide reference clinical materials to facilitate the development and evaluation of new tests. Specimens comprising of serum, plasma, buffy coat, saliva, urine and CSF will be collected from various sites in endemic countries, taking into account geographical variability and differences in patient subgroups. Collection will follow internationally acceptable guidelines regarding the collection, transportation, storage and use of clinical specimens, including control of confidential information such as patient data.

The project plans to enroll around 840 cases, defined as persons with evidence of parasites in their blood, lymphatic system or cerebrospinal fluid (CSF); 840 to 1,000 controls defined as persons with neither evidence nor suspicion of HAT; and 100 to 250 suspected cases defined as persons with a serological suspicion of HAT due to T.b. gambiense but with no evidence of the parasite.