Collecting evidence for scaling up of liquid culture in high TB endemic countries

19 January 2010

A paper published in the International Journal for Tuberculosis and Lung Disease (IJTLD) this month summarizes the methods used and results obtained during the experience of strengthening laboratory diagnosis of tuberculosis in a resource-limited country with high incidence of TB and HIV. The promising evidence for scale up of FIND-developed, new and improved diagnostic technologies became instrumental in obtaining UNITAID support in 2009 to further scale up these tests in 27 high endemic countries under the EXPAND-TB project.

Experience establishing tuberculosis laboratory capacity in a developing country setting (article)

FIND and partners begin research for a Test of Cure for sleeping sickness

17 December 2009

Research has started between FIND, BPRG of the University of Geneva and IPR in Kenya that could lead to the development of a simple method which can confirm that sleeping sickness patients have been cured after treatment for this harmful disease. At present, patient follow-up is uncertain and lengthy, leading many to abandon it altogether.

01 December 2009

After improving and expanding the FIND malaria website content, we have further improved the interactive guide for malaria rapid diagnostic test selection. The interactive guide is intended to help procurers and malaria control programmes select malaria RDTs based on their performance in the WHO-FIND product testing evaluation.

Malaria RDT product testing: interactive guide

Press release on product testing evaluation

Collecting evidence for scaling up of liquid culture in high TB endemic countries

19 January 2010

FIND and partners begin research for a Test of Cure for sleeping sickness

17 December 2009

Enhanced interactive guide for malaria RDT selection

01 December 2009

A large proportion of P. falciparum isolates in the Amazon region of Peru lack pfhrp2 and pfhrp3: implications for malaria rapid diagnostic tests

Gamboa D, Ho M-F, Bendezu J, Torres K, Chiodini P L, Barnwell J W, Incardona S, Perkins M, Bell D, McCarthy J, Cheng Q

Experience establishing tuberculosis laboratory capacity in a developing country setting

Paramasivan CN, Lee E, Kao K, Mareka M, Kubendiran G, Kumar TA, Keshavjee S, Satti H, Alabi G, Raviglione M, Roscigno G

Low-technology cooling box for storage of malaria RDTs and other medical supplies in remote areas

Chanthap L, Ariey F, Socheat D, Tsuyuoka R and Bell D

Within-subject variability of interferon-g assay results for tuberculosis and boosting effect of tuberculin skin testing: a systematic review

van Zyl-Smit RN, Zwerling A, Dheda K, Pai M

Spectrum of latent tuberculosis - existing tests cannot resolve the underlying phenotypes

Pai M.

Improved Models of Mini Anion Exchange Centrifugation Technique (mAECT) and Modified Single Centrifugation (MSC) for Sleeping Sickness Diagnosis and Staging

Büscher P, Ngoyi DM, Kaboré J, Lejon V, Robays J, Jamonneau V, Bebronne N, Van der Veken W, Biéler S

Novel and improved technologies for tuberculosis diagnosis: progress and challenges

Pai M, Minion J, Sohn H, Zwerling A, Perkins M

Quality and reporting of diagnostic accuracy studies in TB, HIV and Malaria: Evaluation using QUADAS and STARD standards

Fontela PS, Pai NP, Schiller I, Dendukuri N, Ramsay A, Pai M

Surveillance of drug-resistant tuberculosis in the state of Gujarat, India

Ramachandran R, Nalini S, Chandrasekar V, Dave PV, Sanghvi S, Wares F, Paramasivan CN, Narayanan PR, Sahu S, Parmar M, Chadha S, Dewan P, Chauhan LS¶

Rapid detection of Mycobacterium tuberculosis and rifampin-resistance using on-demand, near patient technology

Helb D, Jones M, Story E, Boehme C, Wallace E, Ho K, Kop J, Owens M.R., Rodgers R, Banada P, Safi H, Blakemore R, Ngoc Lan N.T., Jones-López E.C., Levi M, Burday M, Ayakaka I, Mugerwa R.D., McMillan B, Winn-Deen E, Christel L, Dailey P, Perkins M.D., Persing D.H., Alland D

Comprehensive new resource for evidence-based TB diagnosis

Pai M, Ramsey A, O'Brien R

An integrated approach to rapid diagnosis of tuberculosis and multidrug resistance using liquid culture and molecular methods in Russia

Balabanova Y, Drobniewski F, Nikolayevskyy V, Kruuner A, Malomanova N, Simak T, Ilyina N, Zakharova S, Lebedeva N, Alexander HL, O'Brien R, Sohn H, Shakhmistova A, Fedorin I

Diagnostic accuracy of commercial urinary lipoarabinomannan detection in African tuberculosis suspects and patients

Mutetwa R, Boehme C, Dimairo M, Bandason T, Munyati SS, Mangwanya D, Mungofa S, Butterworth AE, Mason PR,Corbett EL

Implications of storing urinary DNA from different populations for molecular analyses

Cannas A, Kalunga G, Green C, Calvo L, Katemangwe P, Reither K, Perkins MD, Maboko L, Hoelscher M, Talbot EA, Mwaba P, Zumla AI, Girardi E, Huggett JF for the TB trDNA consortium

First- and second-line drug resistance patterns among previously treated tuberculosis patients in India

Paramasivan CN, Rehman F, Wares F, Sundar Mohan N, Sundar S, Devi S, Narayanan PR

TB diagnostic tests: how do we figure out their costs?

Sohn H, Minion J, Albert H, Dheda K, Pai M

Rapid diagnosis of tuberculosis through the detection of mycobacterial DNA in urine by nucleic acid amplification methods

Green C, Huggett JF, Talbot E, Mwaba P, Reither K, Zumla AI

Regions of differences encoded antigens as targets for immunodiagnosis of tuberculosis in humans

Parkash O, Singh BP, Pai M

Access to antimalarial therapy: accurate diagnosis is essential to achieving long term goals

Hopkins H, Asiimwe C, Bell D

Light-emitting diode technologies for TB diagnosis: what is on the market?

Minion J, Sohn H, Pai M

A combined CXCL10, CXCL8 and H-FABP panel for the staging of human African trypanosomiasis patients

Hainard A, Tiberti N, Robin X, Lejon V, Ngoyi DM, Matovu E, Enyaru JC, Fouda C, Ndung’u JM, Lisacek F, Mueller M, Turck N, Sanchez J-C

Exploiting nanobodies in diagnosis and treatment of African trypanosomiasis

Ndung’u J, Magez S

T-cell interferon-gamma release assays for the rapid immunodiagnosis of tuberculosis: clinical utility in high-burden vs. low-burden settings

Dheda K, Van-Zyl Smit RN, Badri M, Pai M

Epidemiology of antituberculosis drug resistance 2002-07: an updated analysis of the Global Project on Anti-Tuberculosis Drug Resistance Surveillance

Wright A, Zignol M, Van Deun A, Falzon D, Ruesch Gerdes S, Feldmann K, Hoffner S, Drobniewski F, Barrera L, van Soolingen D, Boulabhal F, Paramasivan CN, Kam KM, Mitarai S, Nunn P, Raviglione M

The diagnosis and misdiagnosis of tuberculosis

Davies PDO, Pai M

FIND STRATEGIC APPROACH

TUBERCULOSIS

SLEEPING SICKNESS

MALARIA

COLLECTING EVIDENCE AND SCALE-UP